AXL Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesUFO; JTK11
ProductOrderA
Clone#7E10
Entrez GenelD558
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.
MW97.4kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(19-444)
Catalog#: 20332
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Images
Western Blot
Figure 1: Western blot analysis using AXL mouse mAb against extracellular domain of human AXL (aa19-444).
Figure 1: Western blot analysis using AXL mouse mAb against extracellular domain of human AXL (aa19-444).
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL mouse mAb(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL mouse mAb(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

AXL: AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

References (references)
References (references)1. Br J Cancer. 2006 May 22;94(10):1446-51.
2. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804.