AXL Primary Antibody
Item Information
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Price
Description
AXL: AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Overview
Entrez GenelD
558
Aliases
UFO; JTK11
Clone#
7E10
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ICC (Immunocytochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Br J Cancer. 2006 May 22;94(10):1446-51.
2. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804.
2. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804.
Product Image
Western Blot
Figure 1: Western blot analysis using AXL mouse mAb against extracellular domain of human AXL (aa19-444).
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL mouse mAb(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
For Research Use Only. Not for use in diagnostic procedures.