AURKB Primary Antibody

Item Information
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Description

AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases

Product Overview
Entrez GenelD
9212
Aliases
AURKB
Clone#
13E8D3
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of AURKB expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Song J et al. Immunity 22:621-31 (2005).
2. Kapoor P et al. Mol Cell Biol 25:4934-45 (2005).

Product Image
Western Blot
Figure 1: Western blot analysis using AURKB mouse mAb against truncated AURKB recombinant protein (1) and SKN-SH cell lysate(2).
Figure 1: Western blot analysis using AURKB mouse mAb against truncated AURKB recombinant protein (1) and SKN-SH cell lysate(2).
For Research Use Only. Not for use in diagnostic procedures.