AUP1 Primary Antibody
The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants.
![Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31487ea.jpg?v=1666703769)
![Figure 2:Western blot analysis using AUP1 mAb against human AUP1 (AA: 229-410) recombinant protein. (Expected MW is 46.1 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31487rwb.jpg?v=1666703769)
![Figure 3:Western blot analysis using AUP1 mAb against HEK293 (1) and AUP1 (AA: 229-410)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31487twb.jpg?v=1666703769)
![Figure 4:Western blot analysis using AUP1 mouse mAb against A431 (1), NIH/3T3 (2), Hela (3), SW480 (4), CHO3D10 (5), A549 (6), and SPC-A-1 (7) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31487lwb.jpg?v=1666703769)