ATM Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesAT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; MGC74674; DKFZp781A0353; ATM
ProductOrderA
Clone#5C5
Entrez GenelD472
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human ATM expressed in E. Coli.
MW351kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
2705-2820
Catalog#: 30173
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using ATM mAb against HEK293 (1) and ATM(AA: 2705-2820)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using ATM mAb against HEK293 (1) and ATM(AA: 2705-2820)-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

References (references)
References (references)1. Am J Hum Genet. 2008 Aug;83(2):243-53.
2. Mol Cell. 2008 Jul 25;31(2):167-77.