ARRB1 Primary Antibody
Item Information
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Price
Description
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
Product Overview
Entrez GenelD
408
Aliases
ARB1; ARR1
Clone#
4E11B1
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.
Formulation
Purified antibody from tissue culture in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Natl Cancer Inst. 2011 Feb 16;103(4):317-33.
2. J Clin Immunol. 2011 Jun;31(3):346-55.
2. J Clin Immunol. 2011 Jun;31(3):346-55.
Product Image
Western Blot
Figure 1: Western blot analysis using ARRB1 mAb against human ARRB1 (AA: 89-268) recombinant protein. (Expected MW is 46.3 kDa)
Western Blot
Figure 2: Western blot analysis using ARRB1 mAb against HEK293 (1) and ARRB1 (AA: 89-268)-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.