APP Primary Antibody
Item Information
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Description
Amyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.
Product Overview
Entrez GenelD
351
Aliases
APP
Clone#
1B11F3
Host / Isotype
Mouse / IgG2a
Species Reactivity
Human
Immunogen
Purified recombinant fragment of APP expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Yuzhi Chen, Wenyun Liu, Donna L, et al.J. Cell Biol., Oct 2003; 163: 27.
2. Robert Spoelgen, Christine A. F. von Arnim, et al. J. Neurosci., Jan 2006; 26: 418 - 428.
2. Robert Spoelgen, Christine A. F. von Arnim, et al. J. Neurosci., Jan 2006; 26: 418 - 428.
Product Image
Western Blot
Figure 1: Western blot analysis using APP mouse mAb against truncated APP recombinant protein.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Alzheimer brain tissue, showing cytoplasmic localization using APP mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.