Androgen receptor Primary Antibody
Item Information
Catalog #
Size
Price
Description
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.
Product Overview
Entrez GenelD
367
Aliases
NR3C4; KD; AIS; SMAX1; HUMARA; AR
Clone#
2H8
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human AR expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Chin Med J (Engl). 2009 Nov 20;122(22):2779-83.
2. Taiwan J Obstet Gynecol. 2009 Sep;48(3):262-7.
3. Prostate. 2008 Mar 1;68(4):453-61.
4. Cancer Res. 2007 May 15;67(10):4630-7.
2. Taiwan J Obstet Gynecol. 2009 Sep;48(3):262-7.
3. Prostate. 2008 Mar 1;68(4):453-61.
4. Cancer Res. 2007 May 15;67(10):4630-7.
Product Image
Western Blot
Figure 1: Western blot analysis using Androgen receptor mouse mAb against K562 (1), Jurkat (2) and LNCaP (3) cell lysate.
Western Blot
Figure 2: Western blot analysis using Androgen receptor mAb against human Androgen receptor (AA: 221-321) recombinant protein. (Expected MW is 40 kDa)
Western Blot
Figure 3: Western blot analysis using Androgen receptor mouse mAb against Androgen receptor (aa221-321)-hIgGFc transfected HEK293 cell lysate.
Immunohistochemical analysis
Figure 4: Immunohistochemical analysis of paraffin-embedded human Prostate tissues using Androgen receptor mouse mAb
Immunohistochemical analysis
Figure 5: Immunohistochemical analysis of paraffin-embedded human human testis (left) and prostate cancer (right) tissues using Androgen Receptor mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.