AGT Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesANHU
ProductOrderA
Clone#1B1
Entrez GenelD183
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human AGT expressed in E. Coli.
MW53kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
360-485
Catalog#: 20360
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Images
Western Blot
Figure 1: Western blot analysis using AGT mouse mAb against human plasma (1).
Figure 1: Western blot analysis using AGT mouse mAb against human plasma (1).
Product Overview
Description

AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

References (references)
References (references)1. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1900-7.
2. Regul Pept. 2006 Jan 15;133(1-3):155-9.