AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
2.Biomed Res Int. 2020 Sep 17;2020:5087643.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32401ea.jpg?v=1669029736)
![Figure 2:Western blot analysis using AFP mAb against human AFP (AA: 19-210) recombinant protein. (Expected MW is 52.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32401rwb.jpg?v=1669029736)
![Figure 3:Flow cytometric analysis of HepG2 cells using AFP mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32401fcm.jpg?v=1669029736)
![Figure 5:Immunohistochemical analysis of paraffin-embedded brain tissues using AFP mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32401ihc-1.jpg?v=1669029736)
![Figure 5:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using AFP mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32401ihc-2.jpg?v=1669029736)