AFP

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Description

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4℃; -20℃ for long term storage
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using AFP mAb against human AFP (AA: 19-210) recombinant protein. (Expected MW is 52.3 kDa)
Figure 2:Western blot analysis using AFP mAb against human AFP (AA: 19-210) recombinant protein. (Expected MW is 52.3 kDa)
Immunofluorescence analysis
Figure 3:Flow cytometric analysis of HepG2 cells using AFP mouse mAb (green) and negative control (red).
Figure 3:Flow cytometric analysis of HepG2 cells using AFP mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded brain tissues using AFP mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded brain tissues using AFP mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using AFP mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using AFP mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.