ABL2 Primary Antibody
Item Information
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Price
Description
ABL2(ARG, Abelson-related gene) is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. c-Abl shows both cytoplasmic and nuclear localization,c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.
Product Overview
Entrez GenelD
27
Aliases
ARG; ABLL; FLJ22224; FLJ31718; FLJ41441
Clone#
1H1B11
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of ABL2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ICC (Immunocytochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Yoshimi I, Takashi I, Tsuneyuki O, et al. Blood. 2000; 95(6): 2126-2131.
2. Scheijen, B. and Griffin, J.D. Oncogene. 2002); 21:3314-33.
2. Scheijen, B. and Griffin, J.D. Oncogene. 2002); 21:3314-33.
Product Image
Western Blot
Figure 1: Western blot analysis using ABL2 mouse mAb against truncated ABL2 recombinant protein.
Immunofluorescence analysis
Figure 2: Immunofluorescence staining of methanol-fixed Hela cells using ABL2 mouse mAb showing cytoplasm localization.
For Research Use Only. Not for use in diagnostic procedures.