PSCA CAR-T cells (PSCA scFv-TM-41BB-CD3z)

PSCA (prostate stem cell antigen) is a GPI-linked glycoprotein expressed in the prostate, urinary bladder, placenta, colon, kidney, and stomach. Elevated plasma PSCA levels are found in patients with prostate, pancreas or bladder cancer.

ProMab's PM-CAR1091 primary human CAR-T cells express an anti-PSCA CAR containing a PSCA-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.