EphA2 CAR-T cells (EphA2 scFv-TM-41BB-CD3z)

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Description

EphA2 (ephrin type-A receptor 2) is a type I membrane receptor kinase expressed on a subset of epithelial cells. EphA2 is also expressed in the brain and on glioma cell lines and is overexpressed in a number of cancers.

 

ProMab's PM-CAR1072 primary human CAR-T cells express an anti-EphA2 CAR containing an EphA2-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.

Product Overview
Cell Type Tested
T cells
Formulation
CS10 CryoStor Medium (Sigma Aldrich, Cat, #C2874)
Cell Viability
>90%
Mycoplasma Testing
The cells have been screened using a PCR-based mycoplasma detection kit to confirm the absence of mycoplasma species.
Storage
liquid nitrogen
Shipping & Handing
This product will be shipped in a box containing dry ice at a temperature of -70°C.
For Research Use Only. Not for use in diagnostic procedures.