EphA2 CAR-T cells (EphA2 scFv-TM-41BB-CD3z)

EphA2 (ephrin type-A receptor 2) is a type I membrane receptor kinase expressed on a subset of epithelial cells. EphA2 is also expressed in the brain and on glioma cell lines and is overexpressed in a number of cancers.

ProMab's PM-CAR1072 primary human CAR-T cells express an anti-EphA2 CAR containing an EphA2-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.