CLDN18.2 CAR-T cells (CLDN18.2 scFv-TM-41BB-CD3z)

CLDN18.2 (claudin 18 isoform 2), encoded by the CLDN18 gene, is a multi-pass membrane protein expressed only by stomach epithelial cells. CLDN18.2 is required for the formation of tight junctions in the epithelium and is overexpressed in many gastric cancers.

ProMab's PM-CAR1077 primary human CAR-T cells express an anti-CLDN18.2 CAR containing a CLDN18.2-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.