CD7 CAR-T cells (CD7 scFv-TM-41BB-CD3z)

CD7 is a type 1 membrane protein expressed on lymphocytes including T cells and NK cells. CD7 binding to its ligand K12/SECTM1 acts as a costimulatory molecule via type II phosphatidylinositol-4 kinase, inducing cytokine secretion - IL-2 for T cells, IFN-gamma for NK cells. Anti-CD7 CAR-T cells can be used for T cell malignancies or to block T cell infiltration into solid tumors.

ProMab's PM-CAR1106 primary human CAR-T cells express an anti-CD7 CAR containing a CD7-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.