CD30 CAR-T cells (CD30 scFv-TM-41BB-CD3z)

CD30, encoded by the TNFRSF8 gene, is a type I membrane protein belonging to the tumor necrosis factor receptor superfamily expressed primarily by T cells and B cells. CD30 binding to its ligand TNFSF8/CD30L results in NF-kB activation and cell proliferation. CD30 is expressed in a variety of hematological cancers including Hodgkin's lymphoma and anaplastic large-cell lymphoma (ALCL).

ProMab's PM-CAR1107 primary human CAR-T cells express an anti-CD30 CAR containing a CD30-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.