GPC3-scFv-hinge-TM-CD28-CD3z

GPC3 (glypican-3) is a GPI-linked proteoglycan expressed in hepatocellular carcinoma but not normal liver. GPC3 can also be expressed in other tumors, including melanoma, ovarian clear-cell carcinoma and neuroblastoma. ProMab’s PM-CAR1101 primary human CAR-T cells express an anti-GPC3 CAR containing an alternative GPC3-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain.