CD147 CAR-T cells (CD147 scFv-TM-41BB-CD3z)

CD147, encoded by the BSG gene, is a  type I membrane protein that exists in at least 4 isoforms and mediates multiple cell-cell interactions.  Also known as basigin, CD147 is a prognostic factor in a number of cancers and is thought to promote malignancy by inducing the production of vascular endothelial growth factor (VEGF) in tumor and stromal cells. CD147 is also associated with monocarboxylate transporters, and may therefore be a key metabolic regulator in cancer cells.

ProMab's PM-CAR1075 primary human CAR-T cells express an anti-CD147 CAR containing a fully human CD147-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.