CD133 CAR-T cells (CD133 scFv-TM-CD28-CD3z)

CD133, encoded by the PROM1 gene, is a membrane protein expressed in a number of cell types including hematopoietic stem cells and progenitor cells. Also known as prominin-1, CD133 is thought to be express on cancer stem cells.

ProMab's PM-CAR1018 primary human CAR-T cells express an anti-CD133 CAR containing a CD133-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.