B7H4 CAR-T cells (B7H4 scFv-TM-CD28-CD3z)
B7H4 is a type 1 membrane protein expressed by antigen presenting cells. Encoded by the VTCN1 gene, B7H4 inhibits T cell function and is overexpressed in a variety of cancers.
ProMab's PM-CAR1058 primary human CAR-T cells express an anti-B7H4 CAR containing a B7H4-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.