Teplizumab Biosimilar, CD3e mAb
Item Information
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Description
Teplizumab is a humanized IgG1-kappa monoclonal antibody specific for human CD3-epsilon of the T cell receptor complex. Teplizumab, derived from Muromonab, is used to delay the onset of stage 3 in people with stage 2 type 1 diabetes.
Product Overview
Isotype
IgG1 kappa
Source
Produced in a mammalian stable cell line.
Formulation
0.2-uM filtered solution, pH 6.5, no stabilizers or preservatives
Purity
>95% by SDS-PAGE under reducing conditions and HPLC
Endotoxin
<1 EU/mg (LAL method)
Specificity/Sensitivity
Binds to human CD3-epsilon.
Storage
4°C if used within 1 month, -20°C otherwise
Shipping Information
Shipped with an ice pack.
Application
ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and assays for studying the biological pathways affected by Teplizumab.
For Research Use Only. Not for use in diagnostic procedures.