Natalizumab Biosimilar, Human alpha-4 Integrin mAb
Item Information
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Description
Natalizumab is a humanized IgG4-kappa monoclonal antibody specific for human alpha-4 integrin. Integrin alpha-4 facilitates adhesion and migration of mononuclear immune cells. Natalizumab is used to prevent migration of autoimmune lymphocytes to areas of inflammation in Crohn's disease and multiple sclerosis. This Natalizumab biosimilar has the same amino acid sequence as Natalizumab.
Product Overview
Isotype
IgG4 kappa
Source
Produced in the CHO stable cell line.
Formulation
0.2-uM filtered solution, pH 6.0, no stabilizers or preservatives
Purity
>95% by SDS-PAGE under reducing conditions and HPLC
Endotoxin
<1 EU/mg (LAL method)
Specificity/Sensitivity
Binds to human alpha-4 integrin.
Storage
4°C if used within 1 month, -20°C otherwise
Shipping Information
Shipped with an ice pack.
Application
ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and assays for studying the biological pathways affected by Natalizumab.
For Research Use Only. Not for use in diagnostic procedures.