Denosumab Biosimilar, Human RANKL mAb
Item Information
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Description
Denosumab is a human IgG2-kappa monoclonal antibody specific for human RANKL, the primary signal for bone removal. Denosumab is used for osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone.
Product Overview
Isotype
IgG2 kappa
Source
Produced in the CHO stable cell line.
Formulation
0.2-uM filtered solution, pH 5.2, no stabilizers or preservatives
Purity
>95% by SDS-PAGE under reducing conditions and HPLC
Endotoxin
<1 EU/mg (LAL method)
Specificity/Sensitivity
Binds to human RANKL.
Storage
4°C if used within 1 month, -20°C otherwise
Shipping Information
Shipped with an ice pack.
Application
ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and assays for studying the biological pathways affected by Denosumab.
For Research Use Only. Not for use in diagnostic procedures.