Daclizumab Biosimilar, Human CD25 mAb
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Description
Daclizumab is a humanized IgG1 monoclonal antibody that binds to human CD25 which is expressed by activated T cells. CD25 binding to its ligand IL-2 promotes T cell division. Daclizumab binding to CD25 prevents it from binding to IL-2; therefore, Daclizumab is used to suppress T cell responses in relapsing Multiple Sclerosis and organ transplantation. This Daclizumab biosimilar has the same amino acid sequence as Daclizumab.
Product Overview
Isotype
IgG1 kappa
Source
Produced in the CHO stable cell line.
Formulation
0.2-uM filtered solution, pH 6.0, no stabilizers or preservatives
Purity
>95% by SDS-PAGE under reducing conditions and HPLC
Endotoxin
<1 EU/mg (LAL method)
Specificity/Sensitivity
Binds to human CD25.
Storage
4°C if used within 1 month, -20°C otherwise
Shipping Information
Shipped with an ice pack.
Application
ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and assays for studying the biological pathways affected by Daclizumab.
For Research Use Only. Not for use in diagnostic procedures.