Bevacizumab Biosimilar, Human VEGF mAb
Item Information
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Description
Bevacizumab is a humanized IgG1 monoclonal antibody specific for VEGF-A, a cytokine critical for angiogenesis (the growth of new blood vessels) in both normal tissues and tumors. As the first clinically available angiogenesis inhibitor in the United States, Bevacizumab is used for treatment of certain metastatic cancers, lung cancers, renal cancers, ovarian cancers, breast cancers, and glioblastoma multiforme.
Product Overview
Isotype
IgG1 kappa
Source
Produced in the CHO stable cell line.
Formulation
0.2-uM filtered solution, pH 6.2, no stabilizers or preservatives
Purity
>95% by SDS-PAGE under reducing conditions and HPLC
Endotoxin
<1 EU/mg (LAL method)
Specificity/Sensitivity
Binds to human VEGF-A.
Storage
4°C if used within 1 month, -20°C otherwise
Shipping Information
Shipped with an ice pack.
Application
ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and assays for studying the biological pathways affected by Bevacizumab.
For Research Use Only. Not for use in diagnostic procedures.