Animal Studies

ProMab Biotechnologies has the necessary equipment to perform all the work required for doing small animal imaging and much more with a veterinarian on staff.

We test CAR-T cells in several orthotopic xenograft models, and images metastases using luciferase-positive cell lines. We also provide cancer stem cell models and patient-derived xenograft (PDX) models for testing CAR-T cells.

 ProMab Biotechnologies Custom Chimeric Antigen Receptor Cell Engineering: A complete service, from antigen to clinically relevant solution.

IMAGING SYSTEM SPECIFICATIONS

ANIMAL STUDIES USE CASE: PM-CD19-CAR-T cells

PM-19-CAR-T cells iv injection Raji B-leukemia cells

CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR GROWTH

CD19F-CAR-T IS NOT TOXIC TO MICE (NO LOSS OF MICE BODY WEIGHT)

 
CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR SIZE

 CAR-T CELL MICE HAS INCREASED % HUMAN T CELLS AND % OF HUMAN CD8+ T CELLS

Other Custom Services:

Mouse monoclonal antibodies

Human monoclonal antibodies

Hybridoma Sequencing