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CD197

Order Information
Catalog# Size/Concentration Price
31345 1.0mg/ml $341.00
Specification
Entrez GeneID 1236
Aliases BLR2; EBI1; CCR-7; CCR7; CDw197; CMKBR7; CC-CKR-7
Clone# 4B7B8
MW 42.9kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human;
Immunogen Purified recombinant fragment of human CD197 (AA: extra mix) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application
WB 1/500 - 1/2000
FCM 1/200 - 1/400
ELISA 1/10000
Description
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
References
1.Gastric Cancer. 2017 Mar;20(2):235-245.
2.J Surg Oncol. 2015 Jul;112(1):86-92.
Sequence
extra mix
Related Products

Elisa

Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western Blot

Figure 2:Western blot analysis using CD197 mAb against human CD197 (AA: extra mix) recombinant protein. (Expected MW is 37.5 kDa)

Western Blot

Figure 3:Western blot analysis using CD197 mAb against HEK293 (1) and CD197 (AA: extra mix)-hIgGFc transfected HEK293 (2) cell lysate.

Western Blot

Figure 4:Western blot analysis using CD197 mouse mAb against C6 (1) cell lysate.

Flow cytometric

Figure 5:Flow cytometric analysis of HL-60 cells using CD197 mouse mAb (green) and negative control (red).

Flow cytometric

Figure 6:Flow cytometric analysis of K562 cells using CD197 mouse mAb (green) and negative control (red).