Mouse Monoclonal Antibody to CDKN1B
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| Catalog# |
30044
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| Clone# |
3D8
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| Host and isotype |
Mouse IgG1
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| Species reactivity |
Human
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Lot# |
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| Size |
0.1ml
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Price |
$
280
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| MW |
22kDa
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Entrez Gene |
1027
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| Aliases |
KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B
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| Description |
|
p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
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| Immunogen |
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Purified recombinant fragment of human CDKN1B expressed in E. Coli.
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| Applications |
Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
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| Formulation |
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Ascitic fluid containing 0.03% sodium azide.
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| Storage |
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Store at 4¡æ, for long term storage, store at -20¡æ.
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| Related product |
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| References |
1. Exp Mol Med. 2009 Nov 30;41(11):765-71.
2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18.
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Western Blotting
Figure 1: Western blot analysis using CDKN1B mAb against CDKN1B-hIgGFc transfected HEK293 cell lysate.
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| FOR RESEARCH USE ONLY |
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