Mouse Monoclonal Antibody to SYP
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| Catalog# |
30032
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| Clone# |
7H12
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| Host and isotype |
Mouse IgG1
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| Species reactivity |
Hunam; Rat
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Lot# |
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| Size |
0.1ml
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Price |
$
280
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| MW |
33.8kDa
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Entrez Gene |
6855
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| Aliases |
MRXSYP; SYP
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| Description |
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Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.
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| Immunogen |
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Purified recombinant fragment of SYP expressed in E. Coli.
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| Applications |
Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
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| Formulation |
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Ascitic fluid containing 0.03% sodium azide.
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| Storage |
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Store at 4¡æ, for long term storage, store at -20¡æ.
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| Related product |
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| References |
1. Cancer. 2007 Oct 15;110(8):1776-81.
2. J Gastroenterol Hepatol. 2008 Oct;23(10):1574-85.
3. Virchows Arch. 2009 Aug;455(2):125-32.
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Western Blotting
Figure 1: Western blot analysis using SYP mouse mAb against rat brain tissue lysate.
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| FOR RESEARCH USE ONLY |
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