Mouse Monoclonal Antibody to MATK
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| Catalog# |
20390 Mab-20091012
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| Clone# |
9D7
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| Host and isotype |
Mouse IgG1
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| Species reactivity |
Human
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Lot# |
|
| Size |
0.1ml
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Price |
$
280
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| MW |
56kDa
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Entrez Gene |
4145
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| Aliases |
CHK; CTK
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| Description |
|
MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
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| Immunogen |
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Purified recombinant fragment of human MATK expressed in E. Coli.
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| Applications |
Western Bloting: 1/500 - 1/2000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
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| Formulation |
Antibody are purified by protein G affinity chromatography.
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
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| Storage |
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Store at 4¡æ, for long term storage, store at -20¡æ.
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| Related product |
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| References |
1. Int J Oncol. 2002 Jul;21(1):197-205.
2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
3. Nat Genet. 2004 Jan;36(1):40-5.
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Western Blotting
Figure 1: Western blot analysis using anti-MATK mAb against K562 cell lysate (1).
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FCM
Figure 2: Flow cytometric analysis of K562 cells using anti-MATK mAb (green) and negative control (purple).
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| FOR RESEARCH USE ONLY |
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