Mouse Monoclonal Antibody to FOXA2
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| Catalog# |
20375 Mab-20090922
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| Clone# |
7H4B7
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| Host and isotype |
Mouse IgG1
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| Species reactivity |
Human
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Lot# |
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| Size |
0.1ml
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Price |
$
280
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| MW |
48kDa
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Entrez Gene |
3170
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| Aliases |
HNF3B; TCF3B; MGC19807
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| Description |
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FOXA2 (forkhead box A2), also known as HNF3B (hepatocyte nuclear factor 3, beta). It is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for FOXA2.
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| Immunogen |
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Purified recombinant fragment of FOXA2 expressed in E. Coli.
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| Applications |
Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
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| Formulation |
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Ascitic fluid containing 0.03% sodium azide.
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| Storage |
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Store at 4¡æ, for long term storage, store at -20¡æ.
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| Related product |
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| References |
1. Hepatology. 2008 Aug;48(2):597-606.
2. Cancer Res. 2004 Jun 15;64(12):4137-47.
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Western Blotting
Figure 2: Western blot analysis using FOXA2 mouse mAb against A549 (1) cell lysate.
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IHC-P (paraffin)
Figure 3: Immunohistochemical analysis of paraffin-embedded human colon cancer (A), gastric cancer (B) and rectal cancer (C)tissues using FOXA2 mouse antibody with DAB staining.
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| FOR RESEARCH USE ONLY |
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