Mouse Monoclonal Antibody to PDGFRβ
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| Catalog# |
20358 Mab-2009095
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| Clone# |
1A2
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| Host and isotype |
Mouse IgG1
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| Species reactivity |
Human, Mouse
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Lot# |
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| Size |
0.1ml
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Price |
$
280
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| MW |
190kDa
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Entrez Gene |
5159
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| Aliases |
JTK12; PDGFR; CD140B; PDGFR1; PDGFRB
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| Description |
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Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
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| Immunogen |
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Purified recombinant fragment of human PDGFRβ expressed in E. Coli.
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| Applications |
Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
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| Formulation |
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Ascitic fluid containing 0.03% sodium azide.
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| Storage |
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Store at 4℃, for long term storage, store at -20℃.
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| Related product |
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| References |
1. Biochem Biophys Res Commun. 1997 Jun 27;235(3):455-60.
2. Hum Pathol. 2005 Mar;36(3):242-9.
3. J Virol. 2007 May;81(10):5112-20.
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Western Blotting
Figure 1: Western blot analysis using anti-PDGFRβ mAb against NIH/3T3 cell lysate (1).
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| FOR RESEARCH USE ONLY |
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